Series in Biochemistry
Books in Biochemistry
Biochemistry
Very Short Introductions : Brilliant, Sharp, Inspiring From the simplest bacteria to humans, all living things are composed of cells of one type or another, all of which have fundamentally the same chemistry. This chemistry must provide mechanisms that allow cells to interact with the external world, a means to power the cell, machinery to carry out varied processes within the cell, a structure within which everything runs, and also governance through a web of interlocking chemical reactions. Biochemistry is the study of those reactions, the molecules that are created, manipulated, and destroyed as a result of them, and the massive macromolecules (such as DNA, cytoskeletons, proteins and carbohydrates) that form the chemical machinery and structures on which these biochemical reactions take place. It didn't take long for an understanding of the chemistry of life to turn into a desire to manipulate it. Drugs and therapies all aim to modify biochemical processes for good or ill: Penicillin, derived from mould, stops bacteria making their cell walls. Aspirin, with its origins in willow bark, inhibits enzymes involved in inflammatory responses. A few nanograms of botulinum toxin (botox), can kill by preventing the release of neurotransmitters from the ends of nerves and so leads to paralysis and death, or give a wrinkle free forehead (if administered in very tiny quantities).This Very Short Introduction discusses the key concepts of biochemistry, as well as the historical figures in the field and the molecules they studied, before considering the current science and innovations in the field, and the interaction between biochemistry, biotechnology, and synthetic biology. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.
Caesar's Last Breath
The Guardian 's Best Science Book of 2017: the fascinating science and history of the air we breathe. It's invisible. It's ever-present. Without it, you would die in minutes. And it has an epic story to tell. In Caesar's Last Breath , New York Times bestselling author Sam Kean takes us on a journey through the periodic table, around the globe, and across time to tell the story of the air we breathe, which, it turns out, is also the story of earth and our existence on it. With every breath, you literally inhale the history of the world. On the ides of March, 44 BC, Julius Caesar died of stab wounds on the Senate floor, but the story of his last breath is still unfolding; in fact, you're probably inhaling some of it now. Of the sextillions of molecules entering or leaving your lungs at this moment, some might well bear traces of Cleopatra's perfumes, German mustard gas, particles exhaled by dinosaurs or emitted by atomic bombs, even remnants of stardust from the universe's creation. Tracing the origins and ingredients of our atmosphere, Kean reveals how the alchemy of air reshaped our continents, steered human progress, powered revolutions, and continues to influence everything we do. Along the way, we'll swim with radioactive pigs, witness the most important chemical reactions humans have discovered, and join the crowd at the Moulin Rouge for some of the crudest performance art of all time. Lively, witty, and filled with the astounding science of ordinary life, Caesar's Last Breath illuminates the science stories swirling around us every second.
Dr. Panofsky and Mr. Tarkington: An Exchange of Letters, 1938-1946(With: Erwin Panofsky,Richard Ludwig)
The description for this book, Dr. Panofsky and Mr. Tarkington: An Exchange of Letters, 1938-1946, will be forthcoming.
Oxygen
Oxygen has had extraordinary effects on life. Three hundred million years ago, in Carboniferous times, dragonflies grew as big as seagulls, with wingspans of nearly a metre. Researchers claim they could have flown only if the air had contained more oxygen than today - probably as much as 35 per cent. Giant spiders, tree-ferns, marine rock formations and fossil charcoals all tell the same story. High oxygen levels may also explain the global firestorm that contributed to the demise of the dinosaurs after the asteroid impact. The strange and profound effects that oxygen has had on the evolution of life pose a riddle, which this book sets out to answer. Oxygen is a toxic gas. Divers breathing pure oxygen at depth suffer from convulsions and lung injury. Fruit flies raised at twice normal atmospheric levels of oxygen live half as long as their siblings. Reactive forms of oxygen, known as free radicals, are thought to cause ageing in people. Yet if atmospheric oxygen reached 35 per cent in the Carboniferous, why did it promote exuberant growth, instead of rapid ageing and death? Oxygen takes the reader on an enthralling journey, as gripping as a thriller, as it unravels the unexpected ways in which oxygen spurred the evolution of life and death. The book explains far more than the size of ancient insects: it shows how oxygen underpins the origin of biological complexity, the birth of photosynthesis, the sudden evolution of animals, the need for two sexes, the accelerated ageing of cloned animals like Dolly the sheep, and the surprisingly long lives of bats and birds. Drawing on this grand evolutionary canvas, Oxygen offers fresh perspectives on our own lives and deaths, explaining modern killer diseases, why we age, and what we can do about it. Advancing revelatory new ideas, following chains of evidence, the book ranges through many disciplines, from environmental sciences to molecular medicine. The result is a captivating vision of contemporary science and a humane synthesis of our place in nature. This remarkable book will redefine the way we think about the world.
Two O'Clock Eastern Wartime Export
Widely acclaimed for his groundbreaking crime novels Booked to Die and The Bookman's Wake, award-winning author John Dunning triumphantly returns with a riveting new thriller that takes us back to the summer of 1942, when radio was in its prime, when daylight saving time gave way to "wartime," when stations like WHAR on the New Jersey coast struggled to create programming that entertained and inspired a nation in its dark hour. Into this intense community of radio artists and technicians in Regina Beach, New Jersey, come Jack Dulaney and Holly Carnahan. They are determined to find Holly's missing father, whose last desperate word came from this noisy seaside town. Holly sings like an angel and has what it takes to become a star. Jack -- a racetrack hot-walker and novelist who's hit every kind of trouble in his travels from sea to sea -- tries out as a writer at WHAR and soon discovers a passion for radio and a natural talent for script writing. While absorbing the ways of radio, from writing to directing, he meets some extraordinarily brave and gifted people who touch his life in ways he could not have imagined -- actresses Rue, Pauline, and Hazel; actor-director Waldo, creator of the magnificent black show Freedom Road; and enigmatic station owner Loren Harford, among others. Jack's zeal for radio is exceeded only by his devotion to Holly, who needs his help but who is terrified for his safety. Strange things are happening in Regina Beach, starting with an English actor who walked out of the station six years ago and was never seen again. And Holly's father is gone too, in equally puzzling circumstances. As Jack and Holly penetrate deeper into the shadows of the past, they learn that someone will do anything, including murder, to hide some devastating truths. In a stunning novel that transcends genre, John Dunning calls upon his vast knowledge of radio and his incisive reading of history to create a poignant, page-turning work of fiction that sheds new insights on some of the most harrowing events of the twentieth century. Like E. L. Doctorow's Billy Bathgate or Caleb Carr's The Alienist, Dunning's brilliant tale of mystery, murder, and revenge brings to life another time, another place, another world.