Amidst the chaos and frenzy of the final week before Liam and Peyton’s wedding, Jesse's ex-wife manages to escape from her hospital confinement, unleashing terror upon the entire Quantrall family. With a twisted determination for revenge, Karen sets her sights on destroying everything and everyone in her path, even if it means dragging Jesse - now divorced and still scarred by their past relationship - back into her menacing grasp. As tensions rise and danger looms, it becomes a race against time for Jesse to protect his loved ones and keep Karen at bay. Meanwhile, Liam grapples with his own injuries, fearing that the long-awaited honeymoon in Italy may be nothing more than a distant dream as he struggles to stay on his feet.